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1In the multivariate Cox analysis, RBV ranges remained independent and significant outcome predictors.
2No additional benefits of RBV use were observed for both regimens.
3Selection towards a dominant IFN-resistant strain did not occur under standard or PEG-IFN plus RBV.
4Conclusion: Quantitative whole-animal absorption reconstruction is possible and can be validated in vivo using the rBV.
5Only individuals who had completed a course of pegIFN-RBV therapy and had validated outcomes were considered.
6The safety analysis showed more adverse events and a stronger decline of haemoglobin for RBV containing regimens.
7The absorption values correlated strongly with the rBV-based absorption values, confirming the accuracy of the absorption reconstruction.
8Consequently, we found that RBV-resistant phenotype was conferred mainly by host factor and partially by viral factor.
9In about one-third of patients the RBV was within these ranges and in two-thirds it was above.
10Objectives: To evaluate safety and efficacy of RBV in the era of DAAs in chronic HCV Egyptian patients.
11In conclusion, occurrence of HCC is not a rare event during and immediately after peginterferon-alfa-2a plus RBV treatment.
12For muscle and subcutaneous tumors, which have a much lower rBV and absorption, absorption reconstruction was less important.
13Patients on ADJ higher doses of RBV experienced higher rates of anemia and require more erythropoietin without increasing SVR.
14These colonies were mixed together and further treated with high doses of RBV (up to 200 μM).
16Conclusions: Particular amino acid changes in the NS5B region of HCV may correlate with outcomes of IFN plus RBV combination therapy.